Hello,
in 4.1 I had the problem that connecting to remote-console and leaving there inactive, after some time I cannot use it any more (mouse clicks no effect).
I also reported here:
http://lists.ovirt.org/pipermail/users/2016-October/076890.html
This happened only if connected to the vm from admin portal, while from user portal it was ok. 
Now after update to 4.2 both the admin portal and the new vm portal have the same problem, so that if I leave the VM for some minutes I come back and have to close and open again the spice console

The Vm in question is a Fedora 26, but it was something like Fedora 24 I presume in Dec 2016
I tried to disable at all the screen savers features on it but it doesn't depend on it.

Possibly depending on proxy set? I would try to disable it and verify if problems solves. Any one else using websocket proxy has these problems?

Thanks in advance,
Gianluca