Actually, I found a permissions issue in the engine.log:
2020-03-25 21:28:41,662Z ERROR [org.ovirt.engine.core.dal.dbbroker.auditloghandling.AuditLogDirector] (ForkJoinPool-1-worker-14) [] EVENT_ID: VM_DOWN_ERROR(119), VM win-2019 is down with error. Exit message: internal error: qemu unexpectedly closed the monitor: 2020-03-25T21:28:40.324426Z qemu-kvm: -drive file=/rhev/data-center/mnt/nas-01.phoelex.com:_volume2_isostore/41cebb4b-c164-4956-8f44-6426170cd9f5/images/11111111-1111-1111-1111-111111111111/virtio-win_servers_amd64.vfd,format=raw,if=none,id=drive-ua-0b9c28b5-f75c-4575-ad85-b5b836f67d61,readonly=on: Could not open '/rhev/data-center/mnt/nas-01.phoelex.com:_volume2_isostore/41cebb4b-c164-4956-8f44-6426170cd9f5/images/11111111-1111-1111-1111-111111111111/virtio-win_servers_amd64.vfd': Permission denied.
But when I look at that path on the node in question, every folder and the final file have the correct vdsm:kvm permissions:
[root@ovirt-node-01 ~]# ll /rhev/data-center/mnt/nas-01.phoelex.com:_volume2_isostore/41cebb4b-c164-4956-8f44-6426170cd9f5/images/11111111-1111-1111-1111-111111111111/virtio-win_servers_amd64.vfd
-rwxrwxrwx. 1 vdsm kvm 2949120 Mar 25 21:24 /rhev/data-center/mnt/nas-01.phoelex.com:_volume2_isostore/41cebb4b-c164-4956-8f44-6426170cd9f5/images/11111111-1111-1111-1111-111111111111/virtio-win_servers_amd64.vfd
The files were uploaded to the ISO domain using:
engine-iso-uploader --iso-domain=iso_storage upload virtio-win.iso virtio-win_servers_amd64.vfd