No.
I am using the Spice viewer and my Data domain is on NFS. When I open the "Change CD" option in the viewer, I only see ISO's from the ISO Domain.
I haven't found any other way to actually mount an ISO to a VM other then the viewer which kinda sucks. I am used to other environments where I could just mount an ISO to a cdrom in the VM config and it shows up in the OS.
If you can shutdown the VM, you could try to shutdown it and then choose the arrow near "run" and select "run once".
There you can attach an iso: do you see your data domain isos there?
In my case I have isos on block based data domains: I cannot dynamically change cd
due to the bug I reported,