Oliver,
Thanks for the input, I do recall reading that thread before, I'm 99.9% sure it's not the problem here but I will double check, if anything to rule it out. These bricks are new enterprise SSDs that are less than 3 months old with almost 0 wear on them and the issues I'm experiencing only started within hours after upgrading my environment to oVirt 4.3 (and is the same issue other users are complaining about regarding gluster bricks going offline after upgrading to 4.3). I think it's fairly clear that there is a gluster problem in play.