Hi, welcome to oVirt community! Sadly oVirt is not really working out of the box on Debian based distributions.

There was some effort to try making it running there: https://www.ovirt.org/develop/developer-guide/ubuntu.html but it didn't get enough traction within the development team.

The oVirt projects refer to CentOS Stream as it's being developed there, but it's supposed to run on top of any CentOS Stream derived distributions including Red Hat Enterprise Linux, Alma Linux, Rocky Linux, Oracle Linux and so on.

Is there any specific feature provided by Ubuntu that will make it impossible to use a CentOS Stream based distribution instead for running oVirt?

On top of it, all the guest VMs (except the self hosted engine one) can be Ubuntu if needed.