We performed no updates on our infrastructure and since today, on some guests (not all), we see the following error in the libvirtd logs
140085012483328:error:140760FC:SSL routines:SSL23_GET_CLIENT_HELLO:unknown protocol:s23_srvr.c:640:
(process:375537): Spice-WARNING **: reds-stream.c:469:reds_stream_ssl_accept: SSL_accept failed, error=1
Other guests works fine.